The frame features a trellis design up front with large-diameter thin-wall tubing, two central cast plates and two rear side elements made from welded tubing, closed by a rear load-bearing component made from fibreglass reinforced engineering plastics.
The Multistrada 1200 'S' versions are equipped with 48-mm front fork and Sachs rear monoshock, both integrated with the Ducati Skyhook Suspension (DSS) system. This system is characterised by active suspension control, that automatically and continually adjusts damping to maintain a steady attitude regardless of road conditions, reduce the amount of vibration transferred to rider and passenger, and significantly improves riding comfort and stability. The name ""Skyhook"" describes the feel of the bike, which seems to be hooked up to the sky and immune to bumpy terrain. The DSS system processes the inputs from a number of sensors (vertical accelerometers) located on sprung and unsprung components instantly and adjusts compression and rebound damping according to selected Riding Mode so as to minimise the vertical motion caused by the road and maximise riding comfort and stability. In addition to controlling vertical motion on bumpy terrain, the DSS uses the inputs from the Ride-by-Wire system and the pressure sensors of the ABS to adjust damping continually so as to minimise load transfers during transition from braking to acceleration and deceleration, with great benefits in terms of dynamic performance. Rear suspension spring preload adjustment is integrated with the Riding Modes. The system enables the rider to select the different Riding Modes (Sport, Touring, Urban and Enduro), and to change setup conveniently and quickly to suit load conditions and type of trip: riding solo, rider and luggage, riding two-up or two-up with luggage. The DSS recognises customised settings and re-tunes accordingly before starting interaction.